Almost all IZ plays begin with a combination block, where two linemen block one defender. Two on one, as Chip says, this is a power play, not a finesse play.
Going back to our base formation:
And we saw:
Here, the doubled defender is the NT. Kelce gets to the playside of the defender and blocks him - seals him - and Herremans, who was uncovered, comes free to block to his playside (his left) and the two drive the NT. Meanwhile, each of the other linemen go for their numbered targets, all of them going to their playside. Note that Todd ignores the guy coming to the spot he is vacating. Not his problem. It's Lane's problem. Todd, uncovered at the snap, blocks playside. That comes with coaching and trust.